Dwi Jami Indah Nurhasanah
Universitas Gadjah Mada Yogyakarta,Indonesia
Title: Selasih Lalat (Ointment chayote for mole) As Biocontrol long period of Malignant Melanoma
Biography
Biography: Dwi Jami Indah Nurhasanah
Abstract
Malignant melanoma (MM) is the abnormality of the melanocyte cells in long period will be skin cancer to death. MM has indication same as mole that cause people can not difference both of them. Chayote in society is believed can decrease risk of MM. Secondary metabolit, flavonoid and saponin, can prevent proliferation of cancer cells. Ointment is made of chayote extract that safe for sensitive skin. Sampel of chayote based on age that can see from size of chayote, ,1 month (small), 3 month (medium), 5 month (big). Method of research are etanolic extraction, phytochemical test consist of qualitative test, TLC, and Spectrophotometry, and then antiproliferation test using fibroblast cell HDFa in-vitro. The extract is made to be ointment with base PEG 400 and PEG 4000. The result of the research in three kind of extract sampel positive offlavonoid and saponin, and the highest concentration of flavonoid is extract sample 5 month (0,87%), the highest concentration of saponin is extract sample 1 month (12,74%). The concentration of flavonoid is lower than saponin concentration. An antiproliferation test given a sample extract 1 month can inhibit cell growth better. At 90% confidence level between the variation of sample concentration and viability is significantly different, whereas in the sample extract 3-month was not significantly different. Publications conducted in electronic media and print media are also scientific publications in Majalah Obat Tradisional.