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34th International Conference on Oncology Nursing and Cancer Care

Singapore City, singapore

Tsuneo Kobayashi

International cancer detection and prevention center, Japan

Title: A blood tumor marker combination assay(TMCA)produces high sensitivity and specificity for cancer according to the natural history


Biography: Tsuneo Kobayashi


Background: Diagnosis using a specific tumor marker is difficult because the sensitivity of this detection method is under 20%. Herein, a tumor marker combination assay, combining growth-related tumor marker and associated tumor marker (Cancer, 73(7), 1994), was employed. This double-blind tumor marker combination assay (TMCA) showed 87.5% sensitivity as the results, but a low specificity, ranging from 30 to 76%. To overcome this low specificity, we exploited complex markers, a multivariate analysis and serum fractionation by biochemical biopsy.  Thus, in the present study, a combination of new techniques was used to re-evaluate these serum samples.    

Materials and Methods: Three serum panels, containing 90, 120 and 97 samples were obtained from the Mayo Clinic.

Results: The final results showed 80-90% sensitivity, 84-85% specificity, and 83-88% accuracy.

Conclusion: We demonstrated a notable tumor marker combination assay with high accuracy.  This TMCA should be applicable for primary cancer detection and recurrence prevention.