34th International Conference on Oncology Nursing and Cancer Care
Singapore City, singapore
International cancer detection and prevention center, Japan
Title: A blood tumor marker combination assay（TMCA）produces high sensitivity and specificity for cancer according to the natural history
Biography: Tsuneo Kobayashi
Background: Diagnosis using a specific tumor marker is difficult because the sensitivity of this detection method is under 20%. Herein, a tumor marker combination assay, combining growth-related tumor marker and associated tumor marker (Cancer, 73(7), 1994), was employed. This double-blind tumor marker combination assay (TMCA) showed 87.5% sensitivity as the results, but a low specificity, ranging from 30 to 76%. To overcome this low specificity, we exploited complex markers, a multivariate analysis and serum fractionation by biochemical biopsy. Thus, in the present study, a combination of new techniques was used to re-evaluate these serum samples.
Materials and Methods: Three serum panels, containing 90, 120 and 97 samples were obtained from the Mayo Clinic.
Results: The final results showed 80-90% sensitivity, 84-85% specificity, and 83-88% accuracy.
Conclusion: We demonstrated a notable tumor marker combination assay with high accuracy. This TMCA should be applicable for primary cancer detection and recurrence prevention.