Day 1 :
- Oncology Nursing
Session Introduction
Ljerka Pavković
Specialized Hospital for Medical Rehabilitation, Lipik, Croatia
Title: Testimonies of the Nurses from Lipik of the Homeland War
Biography:
Ljerka Pavković works as the assistant director of nursing and head nurse at the Special Hospital for Medical Rehabilitation Lipik. In 2007 she graduated nursing management at the University of Health Applied Sciences in Zagreb. Throughout her carrier, she received additional education in the field of palliative care at CEPAMET at the University of Zagreb and Zagreb's Institute for the Culture of Health. Driven to help people, she initiated and cofounded Palliative Team LiPa and encourages youth participation in volunteerism. She is actively involved in the strategy for the development of palliative care in the Republic of Croatia and comprehensive care for Croatian veterans respectively. Due to her experience of nursing on the battlefield, she promotes training of nurses in correspondence to the crisis and was consequently named president at the Association of Nurses of the Homeland War of the Croatian Nurses Association (HUMS).
Abstract:
The story "Testimonies of the Nurses from Lipik of the Homeland War" was created according to archive photographs collected by war cameramen whose materials were used to write historical documentation for the town of Lipik. The aim was to authentically show the city's tragedy, sufferings of civilians, the supernatural efforts of the defenders of Lipik, human destinies and all the other horrors only war can bring. The destruction and revival of the city with a great historical heritage were witnessed by nurses participating in those war events. Before the Homeland War, Lipik was a beautiful town known for its thermal water, health resort, hundred-year-old park, beautiful promenades, horses, dance halls, pools and everything that can help a healthy person feel healthier and the sick to get the care they need. In the early morning of a summer day, an aerial bombing attack broke off all the beauty of life in Lipik. It was August the 19th 1991, 5 a.m. The children's home, hospital, school, church, stables and civilian objects were all devasted by the falling grenades. How they felt, what they were thinking, what they were doing, how they organized and what was most difficult is told by the surviving nurses who bravely participated and aided defenders and people in the war. After the liberation of Lipik on December 6th, 1991, the city returned to life bit by bit. The contribution of nurses will remain permanently recorded in the history of Lipik and the Republic of Croatia in connection with the organization of palliative care in the country and the Society of Nurses of the Homeland War of the Croatian Association of Nurses.
Yvonne Hsiung
Mackay Medical College,Taiwan
Title: Development and cross-cultural validation of the advance care planning knowledge index (ACPKI)
Biography:
Yvonne Hsiung received her Ph.D. in Palliative Care Nursing in 2011. Being an ethical consultant for terminal patients and family surrogates, her previous research, teaching, and clinical experiences mostly focused on the health promotion, community education, and cultural advance care planning among minority groups in the Greater Chicago Area. She returned to Taiwan in 2012 because her father required cancer care. Now she is at Mackay Medical College teaching courses about Oncology Nursing, Palliative Care, Medical Ethics, Spiritual Nursing Care, and Life and Death Education.
Abstract:
Two cross-cultural studies were conducted to develop and validate a measure, Advance Care Planning Knowledge Index (ACPKI). Specific aims were to assess prior illness experiences and medical information gained to affect end-of-life decision-making. Through item development and refinement, the original scale was reduced from a 32-item ACP knowledge and experience scale among Chinese-American immigrants residing in greater Chicago area (n=211). With satisfactory content validity, internal consistencies of ACP experience (6 items, α = .67) and ACP knowledge (7 items, α = .84), the exploratory factor analysis (EFA) discovered 2 factors. Overseas Chinese scored high on the ACPKI were found highly positively correlated with socioeconomic status, American acculturation, attitudes toward life-sustaining treatment, and palliative care usage. Further cross-cultural EFA and confirmatory factor analysis yielded the same 2-factor structure among hospitalized Taiwanese patients from various areas (n =508). However, in this Taiwanese sample, 3 items related to self-illness and 3 items of self-rated understanding of ACP were suggestively removed from each subscale for better internal consistencies (α = .69 and .84, respectively) and a better model fit (.92). An individual’s knowledge construct specifically related to life-sustaining treatment, advance directives documents, and the communicative process of ACP appeared to be two dimensional (AVE= 67.33, AGFI= .998). We created a data-driven and efficient tool, the 7-item ACPKI with sound psychometric properties. Future research is necessary to replicate studies for temporal stability across heterogeneous samples and structure confirmation. The potential usefulness of the index as outcome measures for ACP intervention programs is discussed.
Danielle Wittal
British Columbia Cancer Agency, British Columbia
Title: Bridging the Gap from the Oncology Setting to Community Care through a cross Canada Environmental Scan
Biography:
Will update soon
Abstract:
Due to the growing number of cancer survivors, there is a need to evaluate the provision of follow-up care in order to ensure patients’ needs are met. An environmental scan was conducted, provincially and nationally, which aimed to gain a broader understanding of survivorship care, highlight any trends and report disparities in care during the transition from the oncology to the community setting. The environmental scan involved gathering data from 9 out of 10 provinces using telephone interviews; relevant documentation was sought and obtained to identify areas of good practice. There was a wide variation in practice across the province and some recommendations for improving care are made. Findings emphasize the need to promote increased patient self-management and self-advocacy. Implications from the study indicate that cancer survivorship is a complex topic which requires communication and coordination across services to ensure a seamless transition.
Demirsoy Gozde
Adnan Menderes University, Turkey
Title: Usage of complementary and alternative therapies in breast cancer patients
Biography:
Demirsoy G currently working as an eminent Faculty member at Adnan Menderes University, Turkey. She has published numerous research papers and articles in reputed journals and has various other achievements in the related studies. She has extended her valuable service towards the scientific community with her extensive research work.
Abstract:
The frequent occurrence of breast cancer, low survival rate, many side effects of treatments and women's health-seeking behavior have caused to increase the usage of complementary and alternative therapies (CAM). In Turkey, breast cancer patients often resorted to CAM methods, but they are tested by limited studies and gain results which do not answer well how frequently they were used and problems were experienced. In this study, we aimed to determine the usage of complementary and alternative treatments in breast cancer patients.
This descriptive study that took the data from total 518 members who got breast cancer diagnosis of an association with cancer. We did not do sampling, but we only reached 437 members who agreed to fill out the questionnaire. Datas were taken by the questionnaire consisting of 28 questions were developed by the researchers and collected via the Internet. Data were analyzed with descriptive statistics and chi-square analysis. It was determined that the majority of women who participating was in the 40-49 age group, married, graduated from university, income and expenses were equivalent and in stage 2. Mostly biological approaches after diagnostic were preferred. 48.7% of women were reported that they used CAM. In the 40-49 age group, married, equivalent income and expenses and patients with the second phase in breast cancer use CAM in the past and now higher than the other groups. The most used CAM method was herbal products for treatment. All the CAM users have used at least one herbal method. Women who were in the survey mostly used CAM because of preventing symptoms. 70% of women also expressed that it partially allowed their recovery. Women got advice and recommendations about CAM methods from their family members (29.6%) and their knowledge (29.6%).The women participating in this study had problems with its costs, conflicting with the treatment and problems such as difficulty to reach more information about methods and lack of access the xi methods. 56.3% of CAM users did not share their situation about CAM with health professionals during their treatments, but they also expressed that they would like to receive counseling about CAM methods during treatment.
As a result, the majority of breast cancer patients used many CAM methods. If the factors which are age, education, stage, and income increase, using CAM also increases and approximately half of the patients did not share using CAM with their medical staff. Medical staff who take care of breast cancer patients need to question the status of CAM use, find out a way them to share their status, give adequate consulting and also must have sufficient information to guide patients.
Tsuneo Kobayashi
International cancer detection and prevention center, Japan
Title: A blood tumor marker combination assay(TMCA)produces high sensitivity and specificity for cancer according to the natural history
Biography:
Kobayashi Tsuneo has completed his Ph.D. at age of 27 years from Tokyo University.He is the director of international cancer detection and prevention center (ICDP).He has published more than 100 papers in reputed journals. He is promoting cancer recurrence and primary cancer prevention program among high-risk groups.
Abstract:
Background: Diagnosis using a specific tumor marker is difficult because the sensitivity of this detection method is under 20%. Herein, a tumor marker combination assay, combining growth-related tumor marker and associated tumor marker (Cancer, 73(7), 1994), was employed. This double-blind tumor marker combination assay (TMCA) showed 87.5% sensitivity as the results, but a low specificity, ranging from 30 to 76%. To overcome this low specificity, we exploited complex markers, a multivariate analysis and serum fractionation by biochemical biopsy. Thus, in the present study, a combination of new techniques was used to re-evaluate these serum samples.
Materials and Methods: Three serum panels, containing 90, 120 and 97 samples were obtained from the Mayo Clinic.
Results: The final results showed 80-90% sensitivity, 84-85% specificity, and 83-88% accuracy.
Conclusion: We demonstrated a notable tumor marker combination assay with high accuracy. This TMCA should be applicable for primary cancer detection and recurrence prevention.
Matthew Fowler
Heart of England NHS Foundation Trust, United Kingdom
Title: Introducing the role of the Advanced Clinical Practitioner in Oncology and Haematology
Biography:
Matt has completed his MSc in nursing as well as extensive post-graduate training in the field of cancer nursing. He is the lead ACP for Oncology and Haematology at a large hospital in Birmingham and regularly lectures both locally as well as internationally; supporting students on the diploma in cancer nursing at the University of Bethlehem in Palestine. Matt’s particular research interests lie in the management of patients with low-risk febrile neutropenia.
Abstract:
In 2015 the haematology and oncology directorate introduced the role of the Advanced Clinical Practitioner (ACP). A nurse practitioner with an extensive background in the specialty was tasked with setting up the service and also employed a trainee ACP to further complement the service. The initial aims and objectives of the service were to gain further academic qualifications to undertake the role as well as gain competency in clinical procedures previously undertaken by the medical team.
Both ACPs completed the Post Graduate Certificate in Advanced clinical practice at Warwick medical school and as they had both already obtained MSc programmes and were qualified non-medical prescribers this was the only academic work required. Procedure competency was required to undertake lumbar punctures, bone marrow biopsies, PICC line insertions and Hickman line removals. Both ACPs were required to maintain chemotherapy administration and apheresis competencies. The trainee ACP focussed primarily on setting up haematology clinics whilst the senior ACP set up clinics in oncology in Birmingham and haematology in the Channel Islands. Within 12 months of setting up the service the trainee ACP achieved all her competencies and both ACPs are undertaking procedures autonomously, running clinics, prescribing chemotherapy, reviewing patients presenting unwell and function at an advanced level within the MDT. Not without its challenges, yet hugely rewarding; plans are already afoot to learn further procedures and expand the team to work in both the inpatient setting as well as the primary care setting to deliver stem cell transplants in patient’s own homes.
Gayathri
Ramaiah Institute of Nursing Education and Research, India
Title: Prevalence of pre-cancerous cervical lesions using visual inspection acetic acid (via) method among women
Biography:
Will update soon
Abstract:
Cervical cancer is the second most common cancer in women worldwide. It accounts for 6% of all cancers in women (WHO).While there are many factors that put women at risk for cervical cancer, which is caused by the human papillomavirus. There is a need for optimal strategies for cervical cancer screening in low-resource settings. VIA can be done in women of all age groups after the onset of sexual activity up to menopause. Higher priority for screening is given to women aged 35 years or more and repeat screening in every 5 years will achieve great impact on incidence and mortality associated with cervical cancer. Objectives of this study were to identify the prevalence of pre-cancerous cervical lesions among women and to find the association between pre-cancerous cervical lesions and selected socio-demographic variables.
Methods
A Cross-sectional descriptive study was conducted in outpatient department (OPD) of Sanjay Nagar and Mathikere urban health center, Bangaluru. To screen for the precancerous cervical lesion, 210 Participant were recruited by Random sampling technique. Data were collected by using structured questionnaire and screening was by visual inspection with acetic acid. The descriptive and inferential statistic was used for analyzing the data.
Results
The finding of the study revealed that the mean age of the woman screened was 36.13 years and 98.1% woman were married, the mean age at menarche was 12.77 years and marriage were 20.28 years. The prevalence of pre-cancerous cervical lesions VIA positive was 1.9% (4 cases out of 210 women screened).
Conclusions
Visual Inspection Acetic acid (VIA) screening is simple, safe, feasible, cost-effective, acceptable and affordable screening test in identifying the pre-cancerous cervical cancer lesions. Age at marriage and type of sanitary pads used had a significant association.Further intervention should aim at educating the community on personal hygiene.
Biography:
Private- NGO. Dedicated to Science & Service. Aim & Objective ~ Family Welfare, Patient-Centric Care with Society at Heart. Ph.D. (anti-endotoximia; Pharma, Nuclear Med., etc., QC; nano & pico tech, 1995); Worked 2 decades for remote rural with Red Cross (Fight Malaria at Home, invented OMARIA). New drugs & medicaments in rural & mass remote-rural at home health care (invdiscovery). Numerous. Assists all (Pvt. & public). Also a heritage scientist (Ph.D. 2008). Low profile. Foot worker. Works 24 x 7.
Abstract:
Restricted dietary components (DC): Vitamins; Histamines; Enzymes; Mushroom; Green plantains; vegetables & crop grown with overuse of insecticides & pesticides (weekly intent clinical monitoring). Immerse such food material in a tub full of running water for an hour ~ de-ionized battery grade water (best). Why? Vitamins & Enzymes assist in bio-synthesis; growth of the existing neoplasias, participate in robustising angiogenesis; also antagonize chemos (shorten blood life; ketones; renal load). Histamines step down body’s natural defense mechanism, assists migration of gone wrong mitochondria towards oxygen-rich locuses. Insecticides & pesticides up-regulate carcinogenic conditions. Milk normally causes gastric inconveniences & flatulence during chemos. Temperate fruits viz., apple not well indicated.
Strongly prohibited DC: Iodine; Sulphates; Phosphates; Phosphorus; anabolic hormones; Vit-A; Colocesia; Tuna & Mackerel fishes : (day to day clinical monitoring with concurrent investigations). Why? Iodine is cholinergic and hence directly assists cell division. Sulphates; Phosphates assists poly paths in enzyme synthesis and in anabolic pathways. Phosphorous assists metastasis especially to soft and spongy tissues (omentum & especially to bladder~prostrate). Colocesia has tumor growth factors (potent). Each one is also interactive with all others with an up-regulation mechanics. Xenobiotics inducers.
Up-regulators: Arsenic (homeo); anabolic hormones; biphasic entities (e.g., gamma-Aminobutyric acid, tramadol, pregabalin); mood makers; anti-diabetes (sitagliptin); etc., effectively masks; radio-chemicals fail most moieties and also provide impetus to the gone wrong mitochondria. Confabulates, confound & fails conventional therapies. Up-regulates cancer process and mechanics.
Prescribed DC (pro synergistic with Conventional Therapies SCT) : Capsicum; Non-Lymphatic cancer require, green chilies; spicy food; nuts & berries; natural glucosamine from the top portion of sugar cane; wheat; flour; rice; rice products; lintels; soups; chowmin; fast food; crabs – crustaceans; egg; meat; butter; clarified butter; mustard oil; brinjal (wild xanthocarpum best); brine; wine; gram & mixed powder (satua); non-iodised salt; ayurvedic medicinal fruits; ascorbates; tannins; maize & its products; minor millets, etc. Special: Tropo-Equatorial citrus fruits. Coconut kernel. Lymphatic cancers require Custard apple; fructose; breathing exercises; Ozone topical; and Yoga. Non-leukemia cancer requires sun-light exposure and ambulation. Leukemias require rest under shade in moist conditions.
Dietary Supplements SCT: Custard apple (annona squ) unripe/ripe is strongly prophylactic & therapeutic against mammary cancer. Kendu (diospyrous melanoxylon) is very effective anti-mitosis; anti-viral and delivers miracle in most of the cancers other than leukemia. The rhizome Mutha (cyperous rotundus) is yeomanly helpful in leukemias; The herbs Prionitis Berelia (ariel parts) & Brinjle (xanthocrapum aerial parts, fruit & seed) is a tumor/cancer anti-angiogenesis and anti-tissue, respectively. Dayana (artemisia vulgaris) is strongly anti-mitosis; process scavenger and disinfectant. Indo medicinal Dalim (punica granatum) is the safe, best, most potent anti-inflammatory cum process scavenger; anti-viral, also trigger opens the eurolithin pathway for drug moiety loaded fooddiet. Lauha vasma (iron ascorbate & monomeric complexes of ferrous carboxylate); Tamra vasma (do) & Kansa-vasma (do); these act on the gone wrong lysosomes and trigger apoptosis, cancer cell death, fail metastasis and effect metastasis withdrawal (especially from bones & lever) ~ Activate dioxygen binding in hemerythrin. Add a hand grinded paste with turmeric & pepper to act as a buffer. These conjointly act as master failer of cancer when given with low-end chemos. All with conventional therapies.
Lifestyle (Nurse) : Hand holding & Storytelling. Act as the sensory organ of the whole health care system by acting as eagle-eyed and owl alert. Maintain dairy. Peer group interaction & correspondence. Invite all and describe how the patient is improving, is God blessed. What a combatant the patient is! What resilient mindset the patient has !; etc. (Patient): Non-leukemia cancer requires sun-light exposure & ambulation. Rest under shade in moist conditions; work & cold, dry winds are deleterious in leukemias. All types ~ Aimless gossip & talk; TV; movie; deep breathing ~ helps. Late to Bed & Late to rising. Be active and engage in work (Save & Except Kidney/Prostrate/Bladder Cancer). (Community) : Must visit your neighborhood cancer patient ~ helps hugely. Communes fight cancer. (Relatives) : This is the time to visit the afflicted. Offer tasty handmade eatables. Stay-put, gossip, reminiscences. Above, feed & forget.
Biography:
Will update soon
Abstract:
Background: Cisplatin is a potent antineoplastic agent for many cancers but causes several levels of gonadal damage. Ovarian toxicity is a major concern of young cancer patients undergoing chemotherapy.
Objective: This study investigated the effect of Cisplatin and supplementation with resveratrol on ovarian function in Sprague-Dawley rats.
Materials and Methods: In this experimental study, 45 female Sprague-Dawley rats with an average weight of 160 gr were divided into 9 groups (n=5/group). Group 1 served as control and received distilled water. Groups 2 and 9 received Cisplatin only. Groups 3, 4, and 5 received different doses of Resveratrol after a single dose of Cisplatin. Groups 6, 7, and 8 received Resveratrol before Cisplatin. At sacrifice, the ovary was analyzed for histopathology, biochemical indices of oxidation and hormonal assay.
Results: Relative and absolute organ weights increased significantly (p=0.001, 0.01) in the prophylactic groups compared to the groups that received Resveratrol after Cisplatin. Also, glutathione, superoxide dismutase, and catalase increased significantly (p=0.047, 0.01, 0.023) in a dose-dependent manner compared to Cisplatin alone group. Malondialdehyde decreased significantly (p=0.001)in the groups that received high dose Resveratrol compared with the control and Cisplatin alone groups. Although oestrogen showed no significant difference within the groups (p=0.48), resveratrol significantly increased progesterone, follicle stimulating hormone and luteinizing hormone levels (p=0.007, 0.001, 0.006) at high doses when compared with Cisplatin alone groups. Ovarian histoarchitecture was best preserved in the prophylactic groups in a dose-dependent manner.
Conclusion: Resveratrol supplementation confers protection and preserves ovarian follicles from Cisplatin toxicity in Sprague-Dawley rats.
Dias, Maria
Portuguese Institute Oncology Porto, Portugal
Title: The importance of patient-centered cancer care in Oncology
Biography:
Maria has worked as a nurse at the Portuguese Institute of Oncology, in Oporto, since 2010 and at the Health Line, a phone service in Portugal, doing medical triage. She holds an MSc in Medical Informatics from the Faculty of Medicine of the University of Porto: her master’s dissertation was ‘Support telephone system to colorectal patients in treatment and follow up’. The project of dissertation continues with a program of Telenursing to follow up to cancer patients.
She is a specialist nurse in community nursing from the Oporto Nursing School. She is a member of the European Oncology Nurse Society, working in the communication working group. She is also a member of the Portuguese Oncology Nurse Society and a co-coordinator from the working group of Young Cancer Nurses in Portugal and works with EONS across Europe. She is part of the scientific council of the not-for-profit organization for cancer patients (CADO) Oncology Patient Supports Centre.
Abstract:
The demand for cancer care is increasing exponentially due to the increasing cancer incidence and the improved efficacy of cancer treatments. The number of new cancer cases will rise from 14.1 million in 2012 to 21.4 million in 2030, according to the World Health Organization International Agency for Research on Cancer.
Communication skills are the foundation of patient-centered cancer care and have been placed high on the agenda by the National Institute of Clinical Excellence guidelines and the National Health Service in the UK as well as the American Society of Clinical Oncology released its first guidance statement on the cost of cancer care in August 2009, affirming that patient-physician cost communication is a critical component of high-quality care.
This progressive recommendation has grown increasingly important in oncology practice today as the high costs of cancer care impose a tremendous financial burden to patients, their families, and the healthcare system.
The communication skills are essential for oncology health professionals, who must regularly adjust their approach to meet the physiologic and psychosocial needs of patients. Timely communication is also needed among multidisciplinary oncology team members, primary care providers, and specialists in palliative and end-of-life care.
The must be communicated to the individual patient, incorporating values, beliefs, culture, ethnicity, and preferred method of communicating. Its importance includes the patient’s family members and social network. The communication can be improved by using effective verbal and nonverbal behaviors.
Patients’ nonverbal behaviors often indicate their concerns, which may include symptoms such as pain or dyspnea, attitudes such as friendliness or dominance, and personality characteristics such as shyness.
The objective of this review is to understand the overall information and communication process with cancer patients. It is essential to deal with information and communication on a personalized basis for each individual, to receive the information the most suitable for a particular case.
Gerry O Hare
Glasgow & Clyde Health Board, Oncology Clinical Nurse Specialist
Title: Co-operation between nurses in the twinned cities of Glasgow and Bethlehem and the development of a Cancer Nursing Diploma at Bethlehem University Palestine
Biography:
Qualified Registered nurse 1989. Completed Diploma Cancer, Masters Cancer Nursing, Certificate in academic practice the University of Glasgow. Non-Medical Prescriber. Clinical Nurse Specialist and Lead Cancer Nurse for Hospital since 1997. Interest in breast/lung cancer/ chemotherapy
Abstract:
Cancer is a serious public health issue in
Support for cancer nurses education was secured from Glasgow Health Board, the office of Lord Provost of
This is an example of motivated nurses from geographical distant countries positively influencing agencies to develop pioneering cancer/palliative care nurse educational high diploma programme at Bethlehem University Palestine. This initiative sends a message to cancer nurses globally to encourage them to cross-cultural, political and geographical barriers to achieving positive outcomes for cancer nurse education.
Ruchir Tandon
Jaypee Hospital, India
Title: Response to Afatinib, an Irreversible EGFR-TKI in a Patient with Advanced Squamous Carcinoma of Lung
Biography:
Dr.Ruchir Tandon obtained his MBBS degree from R.G.Kar Medical College, Calcutta in 2001 and then did Diplomate of National Board in Oncology in 2007 from Dharamshila Cancer Hospital and Research Center, Delhi. He has served in many hospitals of Delhi-NCR and currently, he is a Consultant in Department of Medical Oncology at Jaypee Hospital, Noida, and Bulandshahr. His Thesis is on Capecitabine as a radiosensitizer in squamous cell carcinoma in head and neck. He has a membership of ASCO and ESMO. Has published papers in reputed journals and is actively involved in Onco-research.
He has interest in Targeted therapy and Immunotherapy.
Abstract:
Siva Sanker Reddy
Santhiram College of Pharmacy, India
Title: Lead molecules from chalcones as anti breast cancer agents
Biography:
Siva Sanker Reddy.L has been actively involved in research for last 9 years and interested in drug discovery process. He began his career as a lecturer and at present, he is a professor at Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India. He teaches Medicinal chemistry and Instrumental method of analysis subjects at both UG and PG students and handles projects of chemistry and analysis. He is currently working on antitubercular and antifungal lead molecules and his Indian Patent application for some diazenyl containing chalcone molecules is under process. He has published around 18 articles both in national and international journals.
Abstract:
Cancers figure among the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases and 8.2 million cancer-related deaths in 2012. The number of new cases is expected to rise by about 70% over the next 2 decades. Half of all men and one-third of all women may develop some form of cancer during their lifetime. Among men, the 5 most common sites of cancer diagnosed in 2012 were lung, prostate, colorectum, stomach, and liver cancer. Among women, the 5 most common sites diagnosed were breast, colorectum, lung, cervix, and stomach cancer. Breast cancer is the most common female cancer. According to the American cancer society’s report, about 12% of women in the U.S. may develop some invasive breast cancer during their lifetime. However breast cancer treatment has a complicated process and complication in case of chemotherapy resistance, surgery, and available anti-tumor medication side effects make it more difficult to select the appropriate treatment regimen. Consequently, there is great demand to introduce new active compounds with more anticancer activity and less toxicity.
Methodology & Theoretical Orientation: In our laboratory, 20 synthetic molecules were synthesized and in vitro studies against breast cancer using cell lines MCF-7 and MDA-MB-468 were conducted. Three molecules were selected as lead molecules from the in vitro study results. These three molecules have shown nearly equal or equal potency with that of the standard drug Doxorubicin. In silico activity studies were performed and from this, it may be concluded that these molecules are exhibiting anticancer activity by inhibiting enzyme like topoisomerases or DNA gyrases or Tyrrosine kinases etc.
Findings: The selected compounds are structurally similar to those of tyrosine kinase inhibitor class of drugs(Alectinib, Canertinib) which are available in the market. Irreversible inhibitors provide potent and selective inhibition of tyrosine kinase enzymes. Use of such inhibitors has proved promising in overcoming the tumor resistance encountered with reversible tyrosine kinase inhibitors. Dacomitinib (PF-00299804) is an experimental drug candidate under development by Pfizer for the treatment of non-small-cell lung carcinoma. It is a selective and irreversible inhibitor of EGFR. Irreversible inhibitors4 inactivate their protein target through covalent interaction with a nucleophilic cysteine residue within the nucleotide binding pocket of the kinase domain. The 2-propen-1-one group present in the 3BM, 3GM & 3JM lead molecules can interact with cysteine residue of kinase domain and can be called as irreversible inhibitors of the target.
Mechanism of irreversible tyrosine kinase inhibitors.
Irreversible inhibitors inactivate their protein target through covalent interaction with a nucleophilic cysteine residue within the nucleotide binding pocket of the kinase domain. The 2-propen-1-one which is part of 3BM, 3GM & 3JM lead molecules can interact with cysteine residue of kinase domain and thus can act as irreversible inhibitors of the target.
Qasem Alnasr
Oncology Nursing Examination Board Member at Saudi Commission for Health Specialties, Saudi Arabia
Title: Perceptions of rural nurses extending their role to administer chemotherapy
Biography:
Will update soon
Abstract:
Background: Nurses in rural regions of South Australia are currently administering chemotherapy in centers where this was not previously the case. To prepare these nurses a state-wide chemotherapy education and assessment programme was implemented in 2013. This research project explored the perceptions of nurses working in level-one rural centers administering low-risk chemotherapy protocols.
Objective: The study explored how registered nurses who administer chemotherapy in low-risk chemotherapy services in rural SA perceive their expanded roles and whether they felt equipped with the knowledge and skills required to undertake them.
Methods: This is a qualitative study. Individual interviews were conducted with eight registered nurses working in low-risk chemotherapy centers in rural settings. The data analysis methods were based on critical social theory.
Findings: Four main categories of findings are identified: 1) role extension, preparedness, and self-confidence; 2) chemotherapy services in rural areas; 3) power relationships, referrals and knowledge sustainability; and 4) communication with other cancer settings and professionals. Overall, participants highly valued the service as a valuable support for rural patients with cancer, but they identified areas of concern, including the need to maintain knowledge and skills and to establish their role in referral and follow-up processes.
Keywords: Cancer, Chemotherapy Administration, Extended Role, Rural Nurses, Rural Oncology.
Implications for practice:
This will help authorities such as SA Health and SA Country Health to review, modify and apply any necessary changes to the role of those nurses and their workplaces.
This study may enable other states to learn from the results when implementing similar programmes.
There is a need to develop a chemotherapy education module specific to rural nursing practice that provides regular updates and clinical rotations to a higher chemotherapy administration service.
Nazri Nordin
Universiti Sains Malaysia, Malaysia
Title: STARZ-DRP as a prospective instrument to counsel the cancer patients in community pharmacy settings
Biography:
Nazri Nordin has completed his BPharm and MSc (Clin Pharm) from Universiti Sains Malaysia (USM). At this moment, he is just submitting his thesis for Ph.D. (Pharmacy Practice) at USM. He has published more than 15 papers in several international and domestic journals. Currently, he is a practicing community pharmacist, particularly paying attention to provide patient-oriented instead of business-oriented service in his community pharmacy setting. His work is known as STARZ-DRP has been picked up as a subject in the educational programme in USM. He has given several talks regarding STARZ-DRP in the domestic scientific conferences, seminars, and workshops.
Abstract:
Community pharmacists (CPs) are an absence of an instrument to maneuver CPs to provide extended services, paying particular attention to consult the cancer patients. For that reason, it is necessary to instigate a well-defined instrument for the on-going practice and STARZ-DRP is chosen as a structured and systematic approach to help out CPs to perform that piece of work. STARZ-DRP emerges from the pharmaceutical care concept and was involved in an earlier study to examine its feasibility to put into the authentic operation. Interestingly, it is noted that the approach is potential to maneuver CPs to make an accurate triage action plan as well as identify a wide range of drug-related problems (DRPs). Such course of action is potential to integrate general practitioners (GPs), nurses, and CPs to work hand-to-hand for the benefits of the patients, particularly preventing and resolving DRPs. In addition, the instrument is potential to eliminate CPs’ lack of self-confidence and competent, knowledge, skills, as well as the language barrier, noted among the health-care practitioners. For that reason, it is necessary to ensure the instrument is brought forward to attention as a prospective instrument to counsel the cancer patients and establish a collaborative working relationship among the health-care practitioners.
Xu Xinyi
Nanjing Medical University, China
Title: Establishment of a Scoring Model based on MEWS for Predicting the Risk of Intra-abdominal Infection after Gastric Cancer Surgery
Biography:
Xu Xinyi is a postgraduate student studying at Nanjing Medical University, her major is gastrointestinal cancer care. She has published papers in reputed journals. Her tutor is Xu Qin. She is the dean of Nursing College. She has published more than 40 papers and has been serving as a committee member of Chinese Medical Association.
Abstract:
Objective
To establish a simple, effective and practical scoring model based on MEWS for predicting a risk of intra-abdominal infection (IAI) after gastric cancer surgery in order to identify and nurse high-risk patients.
Methods
A retrospective study was conducted on 683 patients with gastric cancer surgery. The risk factors of IAI were screened by univariate analysis and multiple logistic regression analysis. The risk prediction model was constructed according to the beta value of each risk factor in the model. Hosmer- Lemeshow test and the receiver operating characteristic (ROC) curve were used to evaluate the predictive compliance degree and discriminant validity of the model. The cut-off value of risk factors was determined according to ROC curve and Youden index and the classification criteria of IAI risk was determined based on the cut-off value and score.
Results
IAI rate was 9.22%. A established scoring model of IAI risk were postoperative WBC > 9.95 (1 point), heart rate > 98 (1 point), temperature > 37.5℃ (3 points), abdominal pain (3 points), abdominal distension (4 points). The validation indicated that the scoring system had higher predictive value (AUC = 0.987, 95%CI:0.948 - 0.999, P<0.05) and high goodness of fit (c2=1.152, P = 0.997). The scoring table was further divided into a low-risk group (0~4 point), moderate risk group (5~7 point), high-risk group (8~12 point).
Conclusion
The scoring model for predicting a risk of IAI after gastric cancer surgery is effective and practical. However, a multicenter, large sample prospective study is needed for further validation.
Xu Xinyi
Nanjing Medical University, China
Title: Evaluation of 10-item Identity-Consequence Fatigue Scale for Patient after Gastrointestinal Tumor Surgery
Biography:
Xu Xinyi is a postgraduate student studying at Nanjing Medical University, her major is gastrointestinal cancer care. She has published papers in reputed journals. Her tutor is Xu Qin. She is the dean of Nursing College. She has published more than 40 papers and has been serving as a committee member of Chinese Medical Association.
Abstract:
Objective
To translate the 10-item Identity-Consequence Fatigue Scale and carry out the reliability and validity test and determine the cut-off point.
Methods
The 10-item ICFS was translated into Chinese and adapted to Chinese culture followed the guideline. 74 patients with gastrointestinal tumor were recruited and were investigated by the Chinese version scale. The reliability and validity were tested. The cut-off point is defined by receiver operating characteristic curve and threshold effect analysis.
Results
The Chinese version of ICFS still retained 10 entries and the content validity index was 0.96. Item analysis indicated each item in the critical ratio was significant, and the correlation coefficients to the total scores reached above 0.5. Exploratory factor analysis indicated that Chinese version scale consisted 2 factors which explained 77.337% of total variance, and factor loading was higher than 0.4. Strong correlations were found with cancer-related fatigue. The internal consistency reliability coefficients were 0.928 for total scale, 0.907 and 0.877 for the 2 factors respectively. The criterion validity with cancer-related fatigue is 0.874. The ROC curve showed the Youden index was the largest when the score was 22 according to anxiety and depression. The threshold effect analysis showed the value was 24 according to hand grip. Therefore, the cut-off point of patients after gastrointestinal tumor surgery is 24.
Conclusion
The Chinese version of ICFS-10 has good reliability and validity and can access postoperative fatigue. The cut-off point is 24 and can be used as a warning for the adverse effects on physiological and psychological health.